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Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Host Species: MouseClone: T311Isotype: IgG2aSpecies Reactivity: Human, Dog and Cat. Weakly cross-reacts with Mouse. Others not known.Epitope: aa 1-433Immunogen: Recombinant tyrosinase proteinMolecular Weight: 70-80kDaPositive Control: Melanoma cell lines and MelanomaCellular Localization: Cytoplasmic Ab-1 shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Staining of melanomas with Ab-1 showed tyrosinase in melanotic as well as amelanotic variants. Ab-1 is a useful marker for melanocytes and melanomas. Occasionally a minor band at 55kDa is also detected in Western Blotting Recommended for:Immunohistochemistry (Formalin/paraffin)Western BlottingImmunofluorescenceImmunocytology
