Tamoxifen, 1 G, Each

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Specifications synonym: (z)-1-(p-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-n,n-dimethylethylaminecas number: 10540-29-1linear formula: c6h5c(c2h5)=c(c6h5)c6h4och2ch2n(ch3)2molecular weight: 371.51Ec number: 234-118-0mdl number: mfcd00010454pubchem substance id: 24900307general 'tamoxifen is a selective estrogen response modifier (serm), protein kinase c inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-oht) and endoxifen by cytochrome p450 isoforms cyp2d6 and cyp3a4. In breast cancer, the gene repressor activity of tamoxifen against erbb2 is dependent upon pax2. Blocks estradiol-stimulated vegf production in breast tumor cells.Preparation note tamoxifen is soluble in chloroform at 50 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in methanol, ethanol, 2-propanol and propylene glycol. Stock solutions of tamoxifen can also be prepared in dmso at 10 mm. However, it is practically insoluble in water (solubility is <0.01%, 20° C). Solutions are sensitive to uv light, and dmso solutions are stable when stored at -20° c in the dark.Application tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs91. It has also been used to study its effect on lipopolysaccharide (lps)-induced microglial activation92.Biochem/physiol actions protein kinase c inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (serms) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated vegf production in breast tumor cells.Assay: =99%mp: 97-98 °c(lit.)Solubility: h2o: insoluble <0.1% At 20 °c; chloroform: soluble50 mg/ml, clear, colorless to faintly yellow; 2-propanol: soluble; dmso: soluble; ethanol: soluble; methanol: soluble; propylene glycol: solublestorage temp.: 2-8°Cgene information: human ... Cyp1a2, ebp, esr1, esr2, esrra; rat ... Ar, esr1