Rig1-Like Receptor Antagonist Found In Andrographis. It Decreases Tnf-A-Induced Generation Of Ros, Suppresses Development Of Diabetes, And Inhibits Hsp90 Activity And Induces Apoptosis In Leukemia Cells, Each

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Andrographolide is a labdane diterpene found in andrographis that exhibits antioxidative, antiviral, anti-inflammatory, anti-diabetic, immunomodulatory, anti-metastatic, and anticancer activities. In vitro, andrographolide decreases tnf-a-induced generation of ros and expression of icam-1 and increases levels of glutathione and heme oxygenase 1 (ho-1). Andrographolide also decreases influenza-induced cell mortality in vitro by inhibiting activation of rig1-like receptors (rlrs). Additionally, andrographolide suppresses development of diabetes in vivo by decreasing expression of il-2, il-17, and ifn-? And increasing expression of il-10 and tgf-ß. This compound also decreases production of no, pge2, inos, tnf-a, cox-2, and ifn-ß in lps-stimulated macrophages. In leukemia cells, andrographolide inhibits hsp90 activity, decreases bcr-abl levels, and induces apoptosis.