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Cadherins are a family of transmembrane glycoproteins involved in the Ca2 -dependent cell-cell adhesion that occurs in many tissues. Cadherins are similar in their domain structure, Ca2 and protease sensitivity, and molecular weight. However, these proteins have distinct tissue expression patterns and immunological reactivities. P-Cadherin is localized in placenta while E-Cadherin and N-Cadherin are found in epithelial and neural tissues, respectively. P-Cadherin is an 829 amino acid polypeptide with a putative signal peptide and precursor region, an extracellular domain containing several internal repeats, and a highly hydrophobic transmembrane region. The cytoplasmic domain provides a link to the cytoskeleton through the associated catenin proteins.Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
