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Using Manipulatives, Model The Flow Of Information Through Dna Translation And Transcription Of A Region On The Beta-Hemoglobin Gene, Then Apply The Model To The Mutation Associated With Sickle-Cell Disease And Its Physiological Effects.Pe: Hs-Ls1-1Time Requirements: 3 45-Minute Class Periodssep: Developing And Using Modelsccc: Systems And System Models; Structure And Functiondci: Ls1.A: Structure And Functionusing A Hypothetical Scenario Of An Infant Diagnosed With Sickle Cell Disease, Students Are Introduced To The Process Of Translation By Modeling The Flow Of Genetic Information On A Region Of The Beta Hemoglobin Gene. Students Model Transcription And Translation Using Unique Magnetic Nucleotide Bases, Develop Their Own Protein Translation Model, And Use Clay To Demonstrate The Physiological Effects Of The Sickle Cell Mutation. Equips 1 Group Of Up To 4 Students.Students Follow A Hypothetical Scenario Of An Infant, "Baby Terra," Diagnosed With Sickle Cell Disease. As They Do, They Are Introduced To The Process Of Translation By Modeling The Flow Of Genetic Information On A Region Of The Beta Hemoglobin Gene. In A Series Of Investigations, Students:Model Transcription And Translation Using Unique Magnetic Nucleotide Basesdevelop Their Own Protein Translation Modeluse Clay To Demonstrate The Physiological Effects Of The Sickle Cell Mutationhave Your Students Explore The Question "Why Did Baby Terra Get Sick?" Through Mendelian And Molecular Modeling. Equips 1 Group Of Up To 4 Students And Includes 1-Year Access To Digital Resources That Support 3-Dimensional Instruction For Ngss.Modeling Dna To Protein: Sample Teacher'S Manual
