Mi-503 Is A Potent And Selective Menin-Mll Inhibitor With Ic50 Of 14.7 nm.

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Mi-503 is a potent and selective menin-mll inhibitor with ic50 of 14.7 Nm. It shows pronounced growth suppressive activity in a panel of human mll leukemia cell lines(gi50 at 250 nm-570 nm range), but only a minimal effect in human leukemia cell lines without mll translocations.