It Is Used To Treat Bone Diseases Such As Osteoporosis. It Inhibits Bone Resorption And Osteoclast Formation But Does Not Have Any Effects On Bone Mineralization. It Also Increases D? T Cell Activation And Inhibits Tumor Growth, Each

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Alendronate is a second generation bisphosphonate that exhibits anti-resorptive, anti-inflammatory, immunomodulatory, and anticancer chemotherapeutic activities. Alendronate inhibits bone resorption but does not have any effects on bone mineralization; it also inhibits osteoclast formation and decreases phosphorylation of akt and erk1/2 in vitro. In animal models, alendronate decreases production of th2 and th17 cytokines and eotaxin-2, suppressing antigen-induced pulmonary immune responses. Additionally, this compound increases δγ t cell activation and inhibits tumor growth in vivo.Grade: ≥98%