Calbiochem Phenylarsine Oxide, A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 μM)., Each

Details

A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18μM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56 lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).