Calbiochem Berberine Chloride, A highly potent and selective oxysterol EBI2 (GPR183) agonist (K, Each
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Details
A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4 T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
Additional Information
SKU | 10575411 |
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UOM | Each |
UNSPSC | 12171500 |
Manufacturer Part Number | 20027525MG |
CAS Number | 633-65-8 |
HS Code | 2934999000 |
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UN Number | UN 1544 |
Proper Shipping Name | Berberine hydrochloride |
Packaging Group | PG III |
Hazardous Class | 6.1 (b) |
Label | ![]() |
Molecular Formula | C20H18ClNO4 |
EC Number | 211-195-9 |
Hazard Statement | H301-H312-H315-H319-H332-H335 |
Precautionary Statements | 0 |
Risk Statements | 20/21/22-36/37/38 |
GHS | GHS06,GHS07 |
GHS (Pictogram) | ![]() ![]() |
Safety Statements | 24/25-36-26 |
Hazard Code | X |
Signal Word | Danger |