Calbiochem 2,3-Butanedione 2-Monoxime, An inhibitor of skeletal and cardiac muscle contraction, Each

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An inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2 currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2 release from canine cardiac sarcoplasmic reticulum (SR).