EGF Receptor Mouse, Unlabeled, Clone: 13, BD, Mouse Monoclonal Antibody, Each

Details

Epidermal Growth Factor (EGF) elicits a variety of cellular responses that are initiated by EGF receptor (EGF-R) binding and activation of intrinsic tyrosine kinase activity. Following ligand binding, EGF receptor is autophosphorylated and, in turn, phosphorylates several other endogenous proteins including phospholipase C γ . These events initiate a number of intracellular responses that include increased levels of intracellular Ca2 and transient expression of the nuclear oncogene products c-Myc and c-Fos.