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Reacts with the human form of the 140kDa membrane glycoprotein, P-selectin, formerly known as platelet activation-dependent granule external membrane protein (PADGEM), or granule membrane protein (GMP-140). P-selectin is stored in the α-granules of platelets and the Weibel-Palade bodies of endothelial cells, and is rapidly transported to the plasma membrane upon activation. P-selectin is thought to mediate the initial adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses, and of activated platelets to neutrophils and monocytes in hemostasis. This antibody is a non-blocking monoclonal antibody and is suitable for immunohistochemical staining of formalin-fixed, paraffin embedded, tissue sections. Clone AC1.2 also cross reacts with activated platelets of baboon, and both rhesus and cynomolgus macaque monkeys. The reactivity on resting and activated platelets is similar to that observed on resting and activated platelets of human donors.
