Cd49d Rat Anti-Mouse, Na/Le, Unlabeled, Clone: 9c10 (Mrf4.B), Bd, Rat Monoclonal Antibody, Each

Details:

The 9c10 (mfr4.B) antibody reacts with the integrin α;4 chain (cd49d), which is expressed as a heterodimer with either of two β; chains, β;1 or β;7. The α;4β;1 integrin (vla-4, cd49d/cd29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α;4β;7 integrin (lpam-1) is expressed on peripheral lymphocytes, but on only a small subset of thymocytes. These integrins mediate a variety of cell-cell and cell-matrix interactions, recognizing the ligands vcam-1 (cd106) and fibronectin. Integrin α;4β;7 also preferentially binds to the mucosal vascular addressin, madcam-1. Although the 9c10 (mfr4.B) antibody alone has been reported to have little function-blocking activity, it can augment the inhibitory effects of mab r1-2 (cat. No. 553153), Resulting in almost complete inhibition of vla-4 binding to vcam-1.