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The M-L233 antibody reacts with the low affinity receptor for human IgE, FcεRII/CD23. CD23 is a type II membrane protein which can be expressed by B cells, monocytes, macrophages, eosinophils, platelets, and dendritic cells. CD23 can mediate IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. Soluble CD23 (sCD23) can be released by CD23 cells as a result of proteolytic cleavage of membrane CD23. Larger fragments of sCD23 (e.g., 37-25kDa) retain their IgE-binding capacity whereas smaller fragments (i.e., <12kDa) do not. Soluble CD23 may have immunoregulatory effects on the growth and differentiation of B cells and other cell types.Host Species: MouseClone: M-L233Isotype: IgG1 κSpecies Reactivity: HumanImmunohistochemistry, Immunohistochemistry (Frozen)
