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Concanavalin A (Con A) Is Covalently Attached To Functionalized Biomagplusparticles For Use In Glycoprotein Isolations From Serum And Cellular Extracts.Con A Is A 104,000 Da Protein Comprised Of Four Identical Subunits, And Existsas An Active Dimer Or Tetramer Depending Upon Ph. Its Carbohydrate Bindingpartners Are Α-D-Glucose And Α-D-Mannose With Unmodified Oh Groups Atc-3, C-4, And C-6, And Terminal Glucose Residues Of Proteins And Peptides.Con A Agglutinates Red Blood Cells (Rbcs), Interacts With Immunoglobulinglycopeptides, And Is A Lymphocyte Mitogen. It Binds Some Bacteria.Con A Binding Is Mediated By Metal Ions, Which Stabilize Is Conformation. Eachbinding Site Requires Calcium And Manganese Ions, And Use Of Buffers With Edtaor Other Metal Chelators Will Result In A Loss Of Carbohydrate Binding Ability
