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Specifications Synonym(s): 1,3,5-Estratriene-3,17β-diol; 17β-Estradiol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; DihydrofolliculinFormula: C18H24O2Formula Weight: 272.38CAS No.: 50-28-2Application: β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).Physical form: powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thawBeilstein Registry Number: 1914275EC No.: 200-023-8Melting Point: 176-180°C(lit.)Biochem/physiol Actions: The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.Reconstitution: To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.Empirical Formula (Hill Notation): C6H5ClMg
