anti-PARP10/ARTD10 Clone: 5H11,, Rat Monoclonal Antibody, Each

Details

Specifically detects PARP10/ARTD10 Clone: 5H11 in Human samples, and it is validated for Immunocytochemistry, Western BlottingPoly [ADP-ribose] polymerase 10 (EC 2.4.2.30; UniProt Q53GL7; also known as ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, PARP-10) is encoded by the PARP10 gene (Gene ID 84875) in human. The ARTD/PARP family adenosine diphosphate (ADP)-ribosyltransferases share a conserved catalytic domain. They can be divided into three classes depending on their catalytic activity. The first class members can generate and modify their substrates with polymers of ADP-ribose (PAR), the second class consists of mono-ADP-ribosyltransferases, while the third class members possess no catalytic activity. ARTD10 (PARP10), originally identified as a MYC-interacting protein is the first recognized member of the second class of ARTD enzymes that target substrates for mono-ADP-ribose (mADPr) modification. ARTD10 is the only ARTD family member that contains two ubiquitin-interaction motifs (UIMs), which mediate interaction with polyubiquitin (pUb) chains with Lys63 (K63) linkage. ARTD10 is reported to function as a negative regulator against NF-κB-dependent gene activation by targeting NEMO for mono-ADP-ribosylation and by preventing NEMO ubiquitination with K63-pUb chains.