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Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. α- and β-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. α- and γ-adducins are ubiquitously expressed. In contrast, β-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2 )/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.Host Species: Rabbit; MouseSpecies Reactivity: HumanELISA
