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53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.Host Species: MouseClone: DO-7 BP53-12Isotype: IgG2b IgG2aSpecies Reactivity: Human. Others not known.Epitope: aa 37-45 and aa 20-25Immunogen: Recombinant human p53 proteinMolecular Weight: 53kDaPositive Control: MDA-231, SKBR-3 cells or Colon CACellular Localization: Nuclear Recommended for:Immunohistochemistry (Formalin/paraffin)Western BlottingImmunoprecipitation (Native and denatured)
